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Lead rapporteurs and their team of junior rapporteurs will provide daily scientific overviews and will publish conference summary paper manuscript after the conference in an open-access, peer-reviewed journal.
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An alternative to the combination of antibodies is the development of bifunctional antibodies carrying multiple Env binding sites in a single molecule. An example was presented by Zhiwei Chen (Sy01.01) describing the molecule BiIA-SG, a bispecific anti gp120 and anti CD4 engineered antibody able to protect humanized mice from HIV acquisition. The combination of BiIA-SG with strategies aimed to improve CD8 T cells is a priority of Dr. Chen's team. A new example of antibody mimetics was presented by Mathias Glögl in a poster session (PD01.01), describing anti-V3 DARPins (an acronym for designed ankyrin repeat proteins), which are genetically engineered antibody mimetic proteins.
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